A major winter storm walloped the eastern third of the United States with heavy rain, snow, ice and travel disruptions to close out the week.

The storm was marked by a dramatic temperature contrast with March-like temperatures on the storm's warmer side and a fresh invasion of arctic air on its back edge. As a result, many locations from the Mississippi, Ohio and Tennessee valleys to the interior Northeast that began as rain transitioned to a period of ice and finally snow as the cold air took control.

Surging temperatures combined with soaking rainfall to trigger flash, urban and ice-jam flooding from Ohio to West Virginia, Pennsylvania, New York and part of New England. Rising waters forced road closures and water rescues.

The Rocky River in northern Ohio coming out of its banks due to an ice jam near the marina. (Twitter Photo/NWS Cleveland)

Areas to the south and west of Pittsburgh were hit hard by flooding on Friday morning. The city picked up over 2 inches of rain prior to a changeover to snow.

House rescues were performed in Brady Township, Pennsylvania, due to rising floodwaters, a fireman in New Bethlehem told AccuWeather Extreme Meteorologist Reed Timmer.

Dozens of rivers from the Ohio Valley to the central Appalachians and New England crested near or at minor flood stage on Friday and Friday night, according to the Advanced Hydrologic Prediction Service.

Snow and ice triggered multi-vehicle accidents around Nashville with portions of I-24 east, I-40 west and I-65 north shut down for a time. The Tennessee National Guard was called onto the scene of the I-40 crash to assist in clearing the roadway.

Wintry precipitation was reported as far south as Louisiana and Mississippi on Friday morning.

Over 4,000 flights were delayed across the eastern United States, including major airports along the Northeast's I-95 corridor, according to FlightStats.

Dry, cold conditions will funnel into the East early this week, but another opportunity for snow may arise by the middle of the week. This next round could bring wintry weather to a larger portion of the South.

A line of semi-trucks, tow trucks and cars sits stationary on Interstate 40 westbound as road crews clear up an accident on Friday, Jan. 12, 2018, near Henderson, Tenn. (AP Photo/Adrian Sainz)

Troopers working at a multiple vehicle crash on I-40 at the 120 mm on Friday, Jan. 12, 2018. (Photo/Tennessee Highway Patrol)

The Pine Kill stream experienced an ice jam in the town of Mamakating, New York, on Jan. 12, 2018. (Facebook Photo/New York State Police)

A house in Mamakating, New York, is surrounded by ice and fast-moving water on all sides due to an ice jam. (Facebook Photo/New York State Police)

A tractor trailer spins sideways after hitting slippery roads in Kentucky on Jan. 12, 2018. (Twitter Photo/Kentucky State Police Trooper Corey King)

Many rivers have seen their ice cover broken up. This can lead to jams and flooding. Please share reports with the NWS. Photo of ice on French Creek in Meadville. #clewx #icejams pic.twitter.com/NQAi2YeHlC — NWS Cleveland (@NWSCLE) January 12, 2018

Checking out an ice jam on the Rocky River before road conditions deteriorate. #ohwx @NWSCLE pic.twitter.com/2oJ7MEy6HB — Cory Mottice (@EverythingWX) January 12, 2018

Ice jam on the Ausable River in Au Sable Forks NY. Video starts at noon (17:00Z) and ends at 3pm (20:00Z). They happen fast! #icejam #nywx pic.twitter.com/vO5HJQeCcU — NWS Burlington (@NWSBurlington) January 12, 2018

MAJOR damage from ice jam / river flooding in East Brady, PA along Allegheny River! Now temperatures plummeting behind Arctic front with winter storm warning in effect soon! @breakingweather #floodwarning #eastbrady #pawx pic.twitter.com/LPFPI8kDbl — Reed Timmer (@ReedTimmerAccu) January 12, 2018

Here's a look at the Redbank Creek in Baxter, just outside of Summerville. Portions of Water Street in Summerville are closed due to flooding @WJACTV pic.twitter.com/x3UgX9gTlK — Bridget McClure (@BridgetWJAC) January 12, 2018